George Holford married Jane daughter and heir of Charles Awbrey of Cantriff in Brecknockshire, and widow of Henry Masterson; and by her had issue Thomas Holford and John, twins; Edward, third son, Peter, fourth son, George, Charles and William; also Mary who married William Harcourt of Winshaw, gentleman, 1629, both yet living, 1666. George Holford died 1635 and Thomas Holford of Iscoit, son and heir, died without issue-male. Wherefore his inheritance is descended now unto James Holford of Newborough, son and heir of Peter, the fourth son of George; for all the other brothers of Peter died without issue; but the manor of Iscoit was sold by Thomas Holford, the eldest brother, to Mr. Adams of London. The Lady Mary Cholmondley survived her husband and lived at her manor-house of Holford, which she built anew, repaired and enlarged, and where she died about 1625 aged 63 years or thereabout. King James termed her The Bold Lady of Cheshire.